Formulation and Evaluation of Sumatriptan Succinate Oral Disintegrating Tablets Using Super Disintegrants

Abstract

The main objective of this research work is to formulate and evaluate the oral disintegrating tablets of sumatriptan succinate to provide faster relief from pain to migraine sufferers. The formulations were optimized by incorporating varying composition of croscarmellose sodium and treated agar as super disintegrates. All the excipients are tested for compatibility with model drug, which revealed that there was no physical and chemical interaction occurred. The blend of each formulation was evaluated for precompression parameters before compression. The tablets are prepared by direct compression method. All the excipients are tested for compatibility. The thickness, hardness, friability, weight variation, disintegration time, drug content uniformity, dissolution rate study etc. were evaluated for core tablets. The dissolution rate of prepared tablets was studied using 900 ml of phosphate buffer solution, pH 6.8 at 37 ± 0.5°C and 50 rpm. One tablet was used in each test. Samples of dissolution fluid (5 ml) were withdrawn through a filter at different time intervals (2.5, 5, 10, 15 & 20 min) and assayed for drug content at 226 nm. Based on the dissolution test result TA3 formulation (containing 7.5% Treated Agar) was selected as best formulation among all formulations.