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In Vivo Efficacy of Momordic Charantia Leaves Extract against Rats Infected with Trypanosome Brucei Brucei (Federe Strain

Mazadu M. R., Lawal I.A., Ajanusi O.J.


In vivo study was conducted using thirty adult male rats which were randomly divided into six groups of five rats each. Groups A, B, C, D and E were infected with 1 × 106 of Trypanosomes; Group F was neither treated nor infected. Methanolic leaf extract of Momordica charantia was administered intraperitoneally to rats in groups B, C, D, and E at doses of 100, 200, 500 and 1000 mg/kg body weight, respectively. The groups treated with the extract showed a significant (p<0.05) decrease in body temperature compared to group A. The result of the initial and final live body weights in groups D, E and F were not significantly (p>0.05) different. Whereas groups B and C were significantly different (p<0.05) and group A was highly significant (p<0.01).

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