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Controlled Porosity Osmotic Pump Tablets Containing Esomeprazole Double Walled Microspheres-An Overview

Salini C


Esomeprazole is a BCS 11 compound, proton pump inhibitor used in the treatment of gastric, duodenal ulcer. The half-life of the drug is 4 hour. The drug has poor stability in acidic condition of the stomach. So, it is formulated into small sized and efficient carriers: the microspheres. To improve their residence time, bioadhesive characteristics can be coupled to develop mucoadhesive microspheres. Mucoadhesive microspheres are extensively used in targeted drug delivery due to their advantages like efficient absorption and improved bioavailability of the drugs and a much more intimate contact with the mucus layer, controlled and sustained release of drug from dosage form and exact targeting of drugs to the absorption site. Coating by enteric polymers will help to target the drug action in the intestine, particularly into the ileum region. Microsphere in conventional tablet will have disadvantages like it needs frequency of administration. Osmotic tablet will provide drug release independent of pH, but having the expense of complicated laser drilling. The main advantages of controlled porosity osmotic pump (CPOP) are reduced stomach irritation, no complicated laser-drilling procedures are followed.

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