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A Review on Resealed Erythrocyte as a Newer Drug Carrier System

V Harshitha, D Bhavana, Prasanna Kumar Desu, K Vanitha


Cellular carriers meet several desirable criteria in clinical applications, among the most important being the carrier's biocompatibility and its degradation products, the various carriers used to target drugs to different body tissues. Among these, the most studied erythrocytes have been shown to have greater potential in the delivery of drugs here are currently 30 major products on the market to deliver drug. Carrier erythrocytes have been evaluated for the safety and efficacy of treatments in thousands of human drug administration. Because of their remarkable degree of biocompatibility, biodegradability and a number of other potential benefits, carrier erythrocytes, resealed erythrocytes charged by a drug or other therapeutic agents have been extensively exploited in recent years to provide a wide range of drugs and other bioactive agents temporally and spatially controlled. Biopharmaceuticals, therapeutically significant peptides and proteins, biological, antigens, and nucleic acid-based vaccines are among the recently targeted drugs for delivery using erythrocyte carriers. Carrier erythrocytes are prepared by collecting blood samples from the organism of intreast and separating plasma erythrocytes. The cells are separated by different methods and the product is retained in the erythrocytes, they are eventually resealed and the resulting carriers are then labeled "resealed erythrocytes". Recent research focuses on isolation, methods of drug processing, testing methods and drug delivery resealed erythrocyte applications.

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