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Elemental appraisal on Process Analytical Technology articulated in Pharmaceutical manufacturing

Nirav Panchal, Mr. Pratik M Tailor, Dr. Ashish D. Mishra


The developing interest in enhanced healthcare products has changed the pharmaceutical business. In recent years, the technologies producing quality products have paved the way for good quality products. The instigation of recent tools and technologies has provided a chance for pharmaceutical producers to enhance the quality standards of pharmaceuticals. Process Analytical Technology (PAT) is one amongst the technologies which are used to give timely analysis of crucial quality parameters with the end goal of rising final product quality similarly as reducing manufacturing prices, thereby significantly benefiting the pharmaceutical trade. PAT involves principally on-line or in-line testing, which may be an invasive or non-invasive method that analyzes the sample whereas it's a part of the method stream. There is no sample preparation in the testing, thus saving time and avoiding the possible mistake in sample preparations. In this review, an attempt has been carried out to explore Historical perspective, PAT implementation, PAT Goal, step to implementation, factors limiting the implementation of PAT, and application of PAT.

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