3D Printing Technology: A Concise Review

Mehul Rohit, Himanshu Solanki, Munaf Jiwani, Harsh Pathak, Jeet Pathak


With a constant change in technology and manufacturing processes, the pharma industry needs to continuously upgrade the method or process of manufacturing of a certain dosage form, since past few decades the industry have upgraded various methods and invented new technologies which can make manufacturing of a said dosage form faster but also with minimum or nil error. Hence when a need for upgrade in process is required a novel method “3D Printing” can be considered as an option to manufacture the said dosage form in pharmaceutical industry. Aprecia Pharmaceutical has a, formulation as fast disintegrating tablet, which is 3D printed, and the only 3D printed product as till now approved by USDFA and is marketed in American and European countries only. Recently researchers at Tel Aviv University 3D Printed heart with cells, blood vessels, ventricles and chambers, the heart is about the size of a rabbit’s heart.

Full Text:



Provaggi E, Kalaskar DM (1 Jan, 2017), "3D printing families: Laser, powder, nozzle based techniques. In3D Printing in Medicine", Woodhead Publishing, pp. 21−42.

Jackson MJ, Ahmed W, "Micro and Nanomanufacturing", Volume 2.

Min JK, Mosadegh B, Dunham S, Al'Aref SJ, editors (4 Jul, 2018), "3D Printing Applications in Cardiovascular Medicine", Academic Press.

Kocovic P, editor (30 May, 2017), "3D Printing and Its Impact on the Production of Fully Functional Components: Emerging Research and Opportunities: Emerging Research and Opportunities", IGI Global.

Whitaker M (Jul 2014), "The history of 3D printing in healthcare. The Bulletin of the Royal College of Surgeons of England", Volume 96, Issue 7, pp. 228−229.

Awad RH, Habash SA, Hansen CJ (1 Jan, 2018), "3D Printing Methods. In3D Printing Applications in Cardiovascular Medicine", Academic Press, pp. 11−32.

Prasad LK, Smyth H (2 Jul, 2016), "3D Printing technologies for drug delivery: a review", Drug development and industrial pharmacy, Volume 42, Issue 7, pp. 1019−1031.

Santos AR, Almeida HA, Bártolo PJ (1 Sep, 2013), "Additive manufacturing techniques for scaffold-based cartilage tissue engineering: a review on various additive manufacturing technologies in generating scaffolds for cartilage tissue engineering", Virtual and Physical Prototyping, Volume 8, Issue 3, pp. 175−186.

Turner BN, Gold SA (20 Apr, 2015), "A review of melt extrusion additive manufacturing processes: II. Materials, dimensional accuracy, and surface roughness", Rapid Prototyping Journal, Volume 21, Issue 3, pp. 250−261.

Tian X, Liu T, Wang Q, Dilmurat A, Li D, Ziegmann G (20 Jan 2017), "Recycling and remanufacturing of 3D printed continuous carbon fiber reinforced PLA composites", Journal of cleaner production, Volume 142, pp. 1609−1618.

Gkartzou E, Koumoulos EP, Charitidis CA (2017), "Production and 3D printing processing of bio-based thermoplastic filament", Manufacturing Review, Volume 4, Issue (1).

Gibson I, Rosen DW, Stucker B (2014), "Additive manufacturing technologies", Springer, New York.

P Taylor (2013), "Virtual and Physical Prototyping", pp. 37–41.

Melocchi A, Parietti F, Maroni A, Foppoli A, Gazzaniga A, Zema L (25 Jul 2016), "Hot-melt extruded filaments based on pharmaceutical grade polymers for 3D printing by fused deposition modeling", International journal of pharmaceutics,Volume 509, Issue 1-2, pp. 255−263.

Goyanes A, Kobayashi M, Martínez-Pacheco R, Gaisford S, Basit AW (30 Nov, 2016), "Fused-filament 3D printing of drug products: microstructure analysis and drug release characteristics of PVA-based caplets", International journal of pharmaceutics, Volume 514, Issue 1, pp. 290−295.

Moulton SE, Wallace GG (10 Nov, 2014), "3-dimensional (3D) fabricated polymer based drug delivery systems", Journal of controlled release, Volume 193, pp. 27−34.

Awad A, Trenfield SJ, Goyanes A, Gaisford S, Basit AW (1 Aug, 2018), "Reshaping drug development using 3D printing", Drug discovery today, Volume 23, Issue 8, pp. 1547−1555.

Gibson I, Shi D (1 Dec, 1997), "Material properties and fabrication parameters in selective laser sintering process", Rapid prototyping journal, Volume 3, Issue 4, pp. 129−136.

Fina F, Madla CM, Goyanes A, Zhang J, Gaisford S, Basit AW (25 Apr 2018), "Fabricating 3D printed orally disintegrating printlets using selective laser sintering", International journal of pharmaceutics, Volume 541, Issue 1-2, pp. 101−107.

Taylor SS. "Thermal history correlation with mechanical properties for polymer selective laser sintering (SLS)", (Doctoral dissertation).

Shirazi SF, Gharehkhani S, Mehrali M, Yarmand H, Metselaar HS, Kadri NA, Osman NA (5 May, 2015), "A review on powder-based additive manufacturing for tissue engineering: selective laser sintering and inkjet 3D printing", Science and technology of advanced materials, Volume 16, Issue 3, pp. 033−502.

Olakanmi EO, Cochrane RF, Dalgarno KW (1 Oct, 2015), "A review on selective laser sintering/melting (SLS/SLM) of aluminium alloy powders: Processing, microstructure, and properties", Progress in Materials Science, Volume 74, pp. 401−477.

Dai L, Cheng T, Duan C, Zhao W, Zhang W, Zou X, Aspler J, Ni Y (19 Sep, 2018), "3D printing using plant-derived cellulose and its derivatives: A review", Carbohydrate polymers,

Musazzi UM, Selmin F, Ortenzi MA, Mohammed GK, Franzé S, Minghetti P, Cilurzo F (15 Nov, 2018), "Personalized orodispersible films by hot melt ram extrusion 3D printing", International journal of pharmaceutics, Volume 551, Issue 1-2, pp. 52−59.

Jamróz W, Kurek M, Łyszczarz E, Szafraniec J, Knapik-Kowalczuk J, Syrek K, Paluch M, Jachowicz R (30 Nov, 2017), "3D printed orodispersible films with Aripiprazole", International journal of pharmaceutics, Volume 533, Issue 2, pp. 413−420.

Yi HG, Choi YJ, Kang KS, Hong JM, Pati RG, Park MN, Shim IK, Lee CM, Kim SC, Cho DW (28 Sep, 2016), "A 3D-printed local drug delivery patch for pancreatic cancer growth suppression", Journal of controlled release, Volume 238, pp. 231−241.

Wang J, Goyanes A, Gaisford S, Basit AW (30 Apr, 2016), "Stereolithographic (SLA) 3D printing of oral modified-release dosage forms", International journal of pharmaceutics, Volume 503, Issue 1-2, pp. 207−212.

Robinson S, Kaboodrangi AH, Dunham S, Shepherd R (1 Jan, 2018), "Materials for 3D Printing Cardiovascular Devices. In 3D Printing Applications in Cardiovascular Medicine", Academic Press, pp. 33−59.

Lohmann P, Willuweit A, Neffe AT, Geisler S, Gebauer TP, Beer S, Coenen HH, Fischer H, Hermanns-Sachweh B, Lendlein A, Shah NJ (1 Jan, 2017), "Bone regeneration induced by a 3D architectured hydrogel in a rat critical-size calvarial defect", Biomaterials,;113:158−169.

Fu J, Yu X, Jin Y (25 Mar, 2018), "3D printing of vaginal rings with personalized shapes for controlled release of progesterone", International journal of pharmaceutics, Volume 539, Issue 1-2, pp. 75−82.


  • There are currently no refbacks.