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A Review on Development and Validation of Analytical Method for Simultaneous Estimation of Formoterol Fumarate Dehydrate and Fluticasone Propionate from Bulk and Dry Powder Inhaler Formulation

Soniya S. Satpute, Godge Rahul K, Sagar Magar D

Abstract


To compare the effectiveness of formoterol fumarate dihydrate and fluticasone propionate two combination inhaled corticosteroid/long acting beta–agonist product approved for treatment of chronic obstructive pulmonary disease (COPD) in the US with respect to cost, therapy adherence, and related healthcare utilization. UV– method for formoterol fumarate dihydrate (FFD) and fluticasone propionate (FP) is simultaneous equation method, Absorbance ration method, first order derivative method the wavelength of FFD-236nm, FP-215nm, overlay of FFD and FP is 233nm. The process can be used for routine simultaneous analysis of formoterol fumarate dihydrate and fluticasone propionate in dry powder inhalation formulation. Early dry powder inhalers (DPIs) wear designed for low drug doses in asthma and COPD therapy. This study contains carrier- based formulations and lacked efficient dispersion principles. Therefore, partial engineering and powder processing are increasingly applied to achieve acceptable lung deposition with this poorly designed inhaler.


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