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Using Spectrophotometric Methods, Evaluation of Antibiotic Drug with Different Metals Interaction study, an In Vitro Analysis

Mohammad Razaul Karim, Md. Shahidul Islam

Abstract


The present study describes of interaction studies of cephradine with essential metals. Cephradine is included among the 1st generation of cephalosporin drug class which is active against a wide range of gram positive and gram negative bacteria. By this study, it is observed that cephradine with essential and trace elements of metals present in the body. Cephradine has been interacted with Mg, Mn, Zn and Fe metal salts in vitro. All the reaction conditions were simulated to natural environments.The studies were carried out in buffer at PH 7.4 in variable ratios of drug and metal both at room temperature conditions. It has been observed that almost major proportion of drug is complexes with metals.There is an effect of PH on drug metal complexation. At pH 7.4, it is investigated that cephradine forms complex and interacts with different essential metals. So, the stability constant of these complexes were determined in order to evaluate their possible in vivo implications. By this interaction antibiotic with different essential metals, the activities of antibiotic will be decreased. The ultraviolet spectrophotoetric studies of these complexes were carried out and compared.

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References


Karen Baxter (2008), “Stockley’s Drug Interactions”, eighth edition, Pharmaceutical press, Available from: http://www.serviciofarmaciamanchacentro.es/images/stories/recursos/recursos/docinteres/conciliacion/stockleys%20drug%20interactions%208th%20edition1.pdf. [Accessed 25th June 2017].

Shargel L. (2010), “Comprehensive pharmacy review”, Lippincott Williams & Wilkins,

Herfindal ET, Hirschman JL (Dec 1, 1979), “Clinical pharmacy and therapeutics”, Williams & Wilkins,

Zhang L, Reynolds KS, Zhao P, Huang SM (Mar 1 2010), “Drug interactions evaluation: an integrated part of risk assessment of therapeutics”, Toxicology and applied pharmacology, Volume 243, Issue 2, pp. 134−145.

Butt EM, Nusbaum RE, Gilmoult TC, Didio SL (Mar 1 1956), “Trace metal patterns in disease states: I. Hemochromatosis and refractory anemia”, American journal of clinical pathology, Volume 26, Issue 3, pp. 225−242.

Martell AE, Smith RM. (1974), “Critical stability constants”, New York: Plenum Press,

Davis JA, Leckie JO. (Oct 15 1978), “Surface ionization and complexation at the oxide/water interface II. Surface properties of amorphous iron oxyhydroxide and adsorption of metal ions”, Journal of Colloid and Interface Science, Volume 67, Issue 1, pp. 90−107.

Okamoto OK, Pinto E, Latorre LR, Bechara EJ, Colepicolo P. (Jan 1 2001), “Antioxidant modulation in response to metal-induced oxidative stress in algal chloroplasts”, Archives of Environmental Contamination and Toxicology, Volume 40, Issue 1, pp. 18−24.

Klastersky J, Daneau D, Weerts D (1973), “Antibacterial activity and clinical effectiveness of cephradine”, International journal of experimental and clinical chemotherapy, Volume 18, pp. 191−204.

Canon SR, Dyson PH, Sanderson PJ (1988), “Pseudo membranous colitis associated with antibiotic prophylaxis in orthopedic surgery”, Journal on Bone joint surgery, Volume 70, pp. 600−602.

Filipe P,Almeida RSLS, Rodrigo FG (1996), “Occuptional allergic contact dermatitis from cephalosporins”, Journal on Contact dermatitis, Volume 34, pp. 226−227.


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