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Optimization of Tween 80 and Span 60 on Cream Ethanol Extract the Leaves Matoa (Pometia Pinnata) as an Antioxidant

Leonard Axel Restuinjaya, Eva Susanty Simaremare, Rani Dewi Pratiwi

Abstract


Matoa is one of Papua’s endemic plants that have enormous potential for it is used in health as a nutrient, inhibits early aging process, and lowers the risk of some diseases. Matoa leaves extract (Pometia pinnata) contained compound class of flavonoids, alkaloids, tannins, saponins, terpenoids, and coumarins, so it can be utilized as one source of natural antioxidants that are good for the body. This study aims to determine the effect of Tween 80 and Span 60 on the physical quality of the optimum formula and test the antioxidant activity of ethanol leaves extract of matoa leaves. Determination of optimum formula using Simple Lattice Design (SLD) method. The results showed that the optimum composition was obtained on Tween 80: Span 60 of 50:50%. The cream with this optimum composition had a power of 3.35 cm; pH test 5.9; sticking power 58.60 sec. The optimum formula of ethanol extract of matoa leaves had a potent antioxidant activity potency with IC50 value of 40.6 ppm.


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Cefali LC, Ataide JA, Foglio MA, et al. (2016), “Plant-Based Active Photoprotectants for Sunscreens”, International Journal of Cosmetic Science, pp. 346–353.

Kuspradini H, Pasedan WF, Kusuma IW. Aktivitas Antioksidan dan Antibakteri Ekstrak Daun Pometia pinnata. Jurnal Jamu Indonesia, (2016), Volume 1, Issue 1, pp. 26−34.

Martiningsih NW, Widana GA, Kristiyanti PL. Skrinning Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Daun Matoa (Pometia pinnata) dengan metode DPPH. Prosiding Seminar Nasional MIPA. (2016), pp. 332−338.

Departemen Kesehatan RI. Farmakope Indonesia edisi V. Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan Departemen Kesehatan Republik Indonesia, (2014),

Tungadi R. Teknologi Sediaan Liquida dan Semisolida. Gorontalo: Sagung Seto, (2014)

Walter KA(2002), “Dermatological and Transdermal Formulation”, New York: Marcel Dekker, Inc.

Gotaro DR (2016), “Optimasi komposisi emulgator span 60 dan tween 80 terhadap stabilitas fisik sediaan cold cream ekstrak etanol pelepah pisang Ambon Kuning (Musa paradisiaca .L). Skripsi thesis”, Sanata Dharma University.

Rabima (2017), Uji Stabilitas Formulasi Sediaan Krim Antioksidan Ekstrak Etanol 70% Dari Biji Melinjo (Gnetum Gnemon L.), Volume 2, Issue 1.

Herdiana Y (2017), “Susilo H. Formulasi krim pencerah wajah ekstrak etanol 70% daun ciplukan (Physalis angulata L.)”,

Saprilanti (2015), Evaluasi stabilitas sediaan lotion dari ekstrak tanaman sarang semut (Myrmecodia beccarii Hook.f.). skripsi. Universitas cenderawasih. Jayapura..

Erawati E, Pratiwi D, Zaky M (2015), Pengembangan formulasi dan evaluasi fisik sediaan krim ekstrak etanol 70% daun labu siam (Sechium edule (Jacq.)Swatz). Farmagazine, Volume 3, Issue 1.

Nurlaela ESN, Ikhsanudin A (2012), Optimasi komposisi tween 80 dan span 80 sebagai emulgator dalam repelan minyak atsiri daun sere (cymbopogon citratus (d.c) stapf) terhadap nyamuk aedes aegypti betina pada basis vanishing cream dengan metode Simplex Lattice Design. Jurnal Ilmiah Kefarmasian. Volume 2, Issue 1, pp. 41−54.

Nur LF (2017), Formulasi emulgator tween 80 dan span 80 sediaan krim ekstrak daun duwet (Syzigium cumini (l.) Skeels) dengan minyak zaitun. Skripsi. Program Studi Farmasi Universitas Ngudi Waluyo,

Bolton. (1997), Pharmaceutical Statistics: Practical and Clinical Applications, 3rd Edition. New York: Marcell Dekker, Inc.

Thomson LA, Thaman RR (2006), Species Profiles for Pacific Island.

Dirjen POM (2000), Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta: Departemen Kesehatan RI.

Manda F. (2011), Optimasi Tween 80 Dan Span 80 Sebagai Emulgator Serta Carbopol Sebagai Gelling Agent Dalam Sediaan Emulgel Photoprotector Ekstrak Teh Hijau (Camellia Sinensis L.). Yogyakarta: USD Prees.

Walter KA (2002), Dermatological and Transdermal Formulation. New York: Marcel Dekker, Inc.

Winarsi H. Antioksidan Alami dan Radikal Bebas. Yogyakarta: Kanisius. (2007)

Armstrong N, James K. (1996), Pharmaceutical Experimental Design and Interpretation. London: Taylor and Francis.

Safitri NA, Puspita OE, Yurina V. (2014), Optimasi formula sediaan krim ekstrak stroberi (fragaria x ananassa) sebagai krim anti penuaan. Majalah kesehatan FKUB., Volume 1, Issue 4.

Laverius MF (2011), Opimasi Tween 80 dan Span 80 sebgai Emulsifying Agent serta Carbopol sebagai Gelling Agent dalam Sediaan Emulgel Photoprotector Ekstrak Teh Hijau (Camelia sinensis L.): Aplikasi Desain Faktorial, Skripsi, Universitas Sanata Dharma, Yogyakarta.

SNI 16-4399-1996. Sediaan Tabir Surya. (2017)

Ayuningrum RP (2016). Uji Stabilitas Fisik dan Penentuan Nilai SPF (Sun Protection Factor) Krim Tabir Surya Ekstrak Kulit Buah Pepaya (Carica Papaya L.). Artikel, Sekolah Tinggi Kesehatan Ngudi Waluyo, Ungaran, Semarang, 4-6 dan 8-9.

Susanti, Kusmiyarsih. Formulasi dan Uji Stabilitas Krim Ekstrak Etanolik Daun Bayam Duri (Amaranthus spinosus L.). Universitas Setia Budi. Surakarta. 2011.

Molyneux P (2004), The Use of the Stable Free Radical Diphenylpicrylhydrazyl (DPPH) for Estimating Antioxidant Activity. Journal Science Technology. Volume 26, Issue2, pp. 211−219.

Andayani AR, Maimunah, Lisawati Y (2008), Penentuan Aktivitas Antioksidan, Kadar Fenolat dan Likopen pada Buah Tomat (Solanum lycopersicum L.). Jurnal Sains dan Teknologi Farmasi. Volume 13, pp. 31−37.


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