Synthesis, Characterisation and Antimicrobial Studies of Ni(Ii) Complex with Schiff Base as Ligand

Abstract

Organometallic compounds have been used in medicine for centuries. Metal complexes play a vital role in pharmaceutical industry and agriculture. Interaction of various metal ions with antibiotics may enhance their antimicrobial activity as compared to that of free ligands. Metal complexes also play a vital role in the treatment of various neurological disorders.Transition metals such as copper,zinc,nickel are involved as transmitters in the neuronalsignalling pathways. This research work discusses,effective drug used as ligands (or) chelating agents that contain atom (or) groups like N,O,S that can attach with metal ion by coordinate linkage to form complexes.This paper deals insynthesis,characterisation and invitro antimicrobial studies of transition metal complex with mixed isoniazid and salicylaldehyde(schiff base)ligand-vitamin drugFT-IR,UV,and NMR. Spectral studies and molar conductance studies show that complex reaction occurred between drug and metal ion.In-vitro antimicrobial studies are undertaken with the Disc diffusion method. Inthe antimicrobial studies,drug-metal complex show greater antimicrobial effect than the sameof a free drug.These findings may be useful for development in future of metal complexes in human biological system.It will offer a platform for design of drug complexes for therapeutic use.