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Functionalities of Purines in Health and Disease
Abstract
Purines conduct several vital cellular functions as in the production of the numeric-precursors of nucleic acids, whereas excess formation of uric acid generated from purines metabolism has been expansively implicated in human disease. The physiological functions and pathogenic attributes of uric acid have been linked to the imminent presentations of cardiovascular abnormalities, diabetes and stroke. Inasmuch as the overproduction of uric acid results in gout, it is established that uric acid constitutes a potent antioxidant in the shielding of DNA from single-strand breaks due to free radicals culminating in a protective effect in neurodegenerative disorders for an extended life span. Thus, this paper describes certain contronymic effects in the functionalities of purines in health and disease.
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